When I built my current PC 3 years back, I had pretty awful noise vs. my previous PC when playing guitar near it. Same flatscreen monitor, same guitar, same (decent) leads, same mains sockets etc. I did a thread on this at the time as the noise heard most was from the hard drive / moving the mouse around the screen.
Turning off C1 in the BIOS improved this a lot but it's still not a quiet board as far as airborne interference goes. Board is an Asus P6X58D and I've read a few on-line whinges about this being a noisy board.
I've recently bought a Kemper - it's wonderful and very, very quiet. And I've noticed that the prevailing noise now (as opposed to amp hum) is coming from the PC - it's the digital chatter stuff, not mains hum, and I only get the issue when I use a single coil guitar. I always carefully screen my guitars so, in most conditions, they hold up pretty well to airborne interference.
I'm using SPDIF from the Kemper into my Focusrite interface. I've also tried the standard monitor outputs which have a ground lift. Same digital noises. It is radiated noise - proximity of guitar to PC sorts it out as does selecting position 2 or 4 on a strat. For critical recording, I can get into a position that minimises the noise (distance plus body angle) but for a general noodle session (what I do most) then I'm sat right in front of the PC practising to Songsterr or similar and the noise is irritating. I love Strat Neck and teles so my taste is my own worst enemy here

To try and put a bit of science into the proceedings, I put my guitar 18" away from my PC and then did the same 18" away from my wife's PC. My wife's PC was much, much better - it is not whacking out anywhere near as much nonsense as mine is and was (to all intents and purposes) quiet. When you consider that her PC case is a standard cheapo and mine is a brick ****house quiet case with loads of (well earthed) metalwork that helps show what a noisy thing my PC mobo is.
Soooo - are the current crop of PC motherboards good in this regard or is it still the case that single coil fans have to sit well away? I don't overly want to do a new build / pay Scan to do it right at this time but may consider it if this will 'fix' my issue. Any other council very gladly received on this matter as well

As an aside, the Kemper is truly lovely. Just had to add that

Thanks
Gary