I'm late to this party so my comments won't necessarily be relevant, and are inevitably subjective and according to my own tastes.
I've been using a Suhr r/l box with built-in IR's for some time (but not used any from other manufacturers). The amp is a 50w PRS Archon, and I also have a PRS single speaker cabinet.
When using the r/l box (into a Focusrite Clarett+ 8pre) I haven't discerned any detrimental HF roll-off or noticeable impact on the overall tone. It's surprisingly close to what I get when using the speaker cabinet. However, this could be subject to the type of guitar/amp combination in front. My EBMM JP15 has powerful humbuckers whose character I would describe as dark, woody, with a pronounced midrange, and the sound of the amp is very much the same. Not a bright sounding combination then, so maybe this is a case of a guitar and amp combination that is well-suited to this load box (and my ears

). Dialling in different IR's changes tonal characteristics to varying degrees, yet the overall character of the guitar/amp is retained.
I've also noted that a compressor in the signal chain, even with moderate settings, helps to tame wayward transients that still manage to creep through despite proper gain-staging and allowing some headroom. Bearing in mind the use of compression will also change tonal characteristics, to one degree or another! I've also experienced no grounding or noise floor issues, which I was concerned about before purchasing the unit.
Prior to the PRS amp I was using a Marshall JVM205C (with an obviously different sound palette), and my experiences were much the same.
I don't own a Strat or Tele, but maybe these guitars with single coils might induce the r/l box to exhibit a more pronounced difference, e.g. significant HF roll-off. Either way, there are lots of variables to consider, but judging by how established most of these type of units now are, most will do the job, subject to personal expectations.
John