I'm going back to the beginning because in threads like these it's so easy to get unintentionally misleading information and go down blind rabbit holes in ever decreasing circles.
Echos wrote: ↑Fri Mar 25, 2022 1:28 pmI'm confident that any noise I hear is coming from the character of the pedals (fuzz, compressor etc) rather than ground loop etc, but this only holds true as long as pedals are in the signal path. If I have pedals that are patched in to the back, powered, but not patched into the signal path (via the front jacks), I get noise.
This is almost certainly because the power supply has isolated and 'floating' outputs, and some of your pedals are digital. The combination means that all manner of interference is being radiated around the unbalanced audio cabling and generating unwanted 'noise'.
This noise increases for each pedal that is powered and not in the signal path. If I patch one of those pedals into the signal path, the noise is reduced. Unpatch it and the noise returns.
When patched the pedals pick up a solid ground from the signal path and that provides effective screening against the radiated interference.
So a patchpanel that allows all connected grounds to be tied to a solid earth would probably help, a lot. Most panels keep each circuit ground separate to reduce the risk of unwanted ground loops... and while that makes sense in many installations, it's not actually helpful in yours.
1. Ferrite chokes on usb cable from computer to audio interface.
No problem with that, as long as it doesn't effect USB reliability.
2. Radial Stagebug SB-6 isolator in between audio interface and speakers, with both grounds lifted, so that the (powered) audio interface becomes the only root to ground for the cables entering the interface (the power supply for the pedals is isolated).
Looking at your schematic, there is no ground for the interface in this arrangement. The guitar isn't grounded. The effects pedals aren't grounded. The interface could be grounded via the USB and computer... except that the computer probably isn't grounded either. (I can't remember what you've done about the iMac power supply).
The speakers possibly are grounded, and since you're using balanced connections between the interface and speakers (which reduces the risk of ground noise getting into the audio signal path), I'd try removing the SB6 to ensure the interface (and iMac) are grounded via that route alone.
3. Swapped out my MXR power supply with a Voodoo Labs Pedal Power 3 Plus which is fully isolated and seemed less noisy then the MXR.
Fair enough... but be aware that its isolated outputs mean no grounding via the power line for any effects pedal. That is probably helpful, but only if the fx pedals are grounded via another route!
4. Fully isolated the patchbay from the rack using nylon screw collars (and confirmed this with a multimeter)
Probably not helpful in this situation.
Everything runs into the same power-conditioned strip and into a wall socket (240v, 3-pin as I'm in the UK).
The 'power conditioning' of these things is negligible and can actually make the grounding impedance worse rather than better. However, they do have the benefit of encouraging a star power distribution which is a good thing as it minimises the risk of ground loops.
So in the current configuration, the only route to ground for the pedals is through the signal path, into the audio interface and out through its power cable ground.
As per your diagram, there was no ground path as the interface psu was a double-insulated type with a plastic earth pin. There was no ground in the audio signal path anywhere!
My advice would be to use a patchbay in which the screens of all connected inputs can be tied together and, ultimately, to a solid earthing ground. That should keep your pedals quiet and stop them radiating noise when not in use.
I'd also remove the stagebug so that the interface acquires a ground from the mains-powered speakers (assuming they are themselves class-1 and grounded types). That ground will be passed to the iMac via the USB connection. The chokes may well be unnecessary, but you can experiment with removing them once everything else is sorted.
There is still a possibility that the digital pedals are generating interference which is spreading via the shared power supply (even though they are isolated outputs -- the isolation might not be as good as claimed!). If, after using a grounding patch bay, the noise remains, I would try using individual power supplies on the digital pedals and keep power leads as far apart as possible. Chokes might help on those too!
Hope that helps.
Resolving this kind of problem with unbalanced cabling and multiple sources and destinations can be very tiresome and time consuming, and made even harder by non-real-time remote diagnosis and where the tests and results aren't may inadvertently not be exactly as requested, giving unintentionally misleading results.
But these things can usually be sorted out eventually... so stick with it!